Spider-Man and Venom fit the classic definition of archenemies: they've fought numerous battles, and they have a hatred for each other so strong that nothing could bring them together...until now. In SEPARATION ANXIETY, these two rivals will team up to take on an evil force that threatens humanity. After Venom is split from his living costume, five deadly alien Symbiotes are spawned and the only way to bring them down is to join Spider-Man and battle them as a unit.